Skip navigation

Tips to ease injection site soreness

May 29, 2009


Common side effects of injections include mild, local reactions or irritation at the site of injection, and/or pain, bruising and redness of the skin. Injection site soreness differs with every patient and medication, so if you are experiencing some discomfort after your subcutaneous or intramuscular injections, it may be absolutely normal or you may need to contact your doctor for further examination.


In an effort to help relieve any discomfort you may be experiencing, we’ve compiled a couple of tips to help you ease the pain resulting from your fertility injections.


Prior to beginning your injectable medication cycle, you should notify your doctor of any latex or adhesive sensitivities or allergies so he/she can consider alternative medicines and treatments. Another issue to be aware of is how the use of anticoagulants (blood thinners) or the regular use of aspirin can impact the injection site’s ability to clot. Ask your physician what is right for you. You should be aware that these medications may cause increased bleeding and bruising around the injection site.


Here are a few tips to help ease soreness during and after the injection:

  • Pre-injection: Use a cold pack to numb the surface of the skin
  • If you are doing an intramuscular injection, make sure the muscle is relaxed. If your muscle is tight, it will likely hurt more. (HINT: If standing and injecting in the buttocks, put your weight on the opposite leg and wiggle your toes on the same side as the injection site. Doing this may keep your muscles loose and trick your brain into concentrating on something else)
  • Post-injection: Injection sites usually bother patients the next day, so of you rotate a warm pack on and off the site, it will help blood flow to the area and heal the area faster
  • Post-injection: Massage or rub the site. This will help disperse the medication and loosen the muscle. There are two important exceptions to this rule: Heparin and Lovenox. Do not massage Heparin or Lovenox injection sites. These medications are anticoagulants and massaging these injection sites can lead to bruising
  • If you are concerned about the swelling and redness around an injection site, it is helpful to outline the swelling with a pen or marker. This will help you to determine if it is increasing in size and monitor if and how the injection site is changing. If the swelling or redness increases in size or does not decrease in size, contact your physician. You should contact your physician immediately if you have any questions or concerns about abnormal or unusual redness, swelling or side effects.

Any injection site that continues to be problematic after 48 hours should be seen by your doctor immediately.


Here are a few things to watch for:

  • Increased redness
  • Expanding swelling that is growing worse
  • Fever
  • An injection site that has a warm skin temperature
 If you have any questions about your injections, please feel free to contact Village Fertility Pharmacy at (877) 334-1610. You may also refer to our free, online injection lesson videos by visiting